154.00
Abemaciclib (LY2835219) ≥98%
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价格
154.00
货号
L124851-5mg
市场价
0.00
品牌
阿拉丁
销量
0
库存量
100
CAS号
1231930-82-7
分子式
C27H32F2N8.CH4O3S
分子量
602.7

基本信息

产品名称Abemaciclib (LY2835219)
英文名称Abemaciclib (LY2835219)
别名LY2835219;LY 2835219;LY-2835219
英文别名CDK4/6 dual inhibitor;LY 2835219;LY-2835219;N-[5-[(4-Ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinamine methanesulfonate (1:1)
规格或纯度≥98%
运输条件超低温冰袋运输
生化机理

LY2835219 is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. CDK4/6 dual inhibitor LY2835219 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of the serine/threonine kinases CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.

一般描述

LY2835219对CDK4和CDK6的IC50分别为2 nM和10 nM。


LY2835219 is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively.

相关属性

CAS编号1231930-82-7
溶解性DMSO 83 mg/mL Water 100 mg/mL Ethanol 24 mg/mL
储存温度-20°C储存
分子量602.7
分子式C27H32F2N8.CH4O3S
品牌阿拉丁
PubChem CID71576678


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