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基本信息
| 产品名称 | Abemaciclib (LY2835219) |
|---|---|
| 英文名称 | Abemaciclib (LY2835219) |
| 别名 | LY2835219；LY 2835219;LY-2835219 |
| 英文别名 | CDK4/6 dual inhibitor;LY 2835219;LY-2835219；N-[5-[(4-Ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinamine methanesulfonate (1:1) |
| 规格或纯度 | ≥98% |
| 运输条件 | 超低温冰袋运输 |
| 生化机理 | LY2835219 is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. CDK4/6 dual inhibitor LY2835219 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of the serine/threonine kinases CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation. |
一般描述
LY2835219对CDK4和CDK6的IC50分别为2 nM和10 nM。
LY2835219 is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively.
相关属性
| CAS编号 | 1231930-82-7 |
|---|---|
| 溶解性 | DMSO 83 mg/mL Water 100 mg/mL Ethanol 24 mg/mL |
| 储存温度 | -20°C储存 |
| 分子量 | 602.7 |
| 分子式 | C27H32F2N8.CH4O3S |
| 品牌 | 阿拉丁 |
| PubChem CID | 71576678 |