￥
31.00起
氯沙坦钾 选择性非肽血管紧张素II AT 1受体拮抗剂 ≥99%
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价格
￥31.00
货号
L129227-1g
市场价
￥0.00
品牌
阿拉丁
销量
0
库存量
100
CAS号
124750-99-8
分子式
C22H22ClKN6O
分子量
461
基本信息
| 产品名称 | 氯沙坦钾 |
|---|---|
| 英文名称 | Losartan Potassium (DuP 753) |
| 别名 | 洛沙坦钾；2-丁基-4-氯-1-[[2'-(1H-四唑-5-基)-1,1'-联苯-4-基]甲基]咪唑-5-甲醇钾；2-丁基-4-氯-1-{[2′-(1H-四唑-5-基)(1,1′-联苯)-4-基]甲基}-1H-咪唑-5-甲醇 单钾盐 |
| 英文别名 | DuP-753 potassium; Cozaar potassium;Losartan potassium salt;2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]imidazole-5-methanol Potassium Salt |
| 应用 | A specific antagonist of the AT1 receptor with significant downstream effects. |
| 规格或纯度 | ≥99% |
| 运输条件 | 常规运输 |
| 生化机理 | Losartan Potassium is a specific antagonist of the angiotensin II receptor subtype AT1. Antagonism of the AT1 receptor and interference of association between AT1 and angiotensin II produces vasodilation and reduction of hypertension. This antagonism has other downstream effects, including a correlated antagonism of the thromboxane A2 receptor, inhibition of platelet aggregation, and induction of peroxisome proliferator-actived receptor gamma (PPARγ) activity.Selective non-peptide angiotensin II type 1 (AT 1 ) receptor antagonist (K i = 10 nM). Blocks classical actions of angiotensin II . Displays antihypertensive action and downregulates TFG-β regulation. Active in vivo . |
一般描述
Losartan potassium is a new drug used for hypertension. It is nonpeptide angiotensin II (AII) receptor antagonist.
Losartan potassium is nonpeptide angiotensin II (AII) receptor antagonist and is orally active. It belongs to a new class of drugs introduced for clinical trials to treat hypertension.
A specific antagonist of the AT1 receptor with significant downstream effects.
A specific antagonist of the AT1 receptor with significant downstream effects.
Losartan potassium is a new drug used for hypertension. It is nonpeptide angiotensin II (AII) receptor antagonist.
Losartan potassium is nonpeptide angiotensin II (AII) receptor antagonist and is orally active. It belongs to a new class of drugs introduced for clinical trials to treat hypertension.
A specific antagonist of the AT1 receptor with significant downstream effects.
A specific antagonist of the AT1 receptor with significant downstream effects.
安全信息
| Merck Index | 5583 |
|---|
相关属性
| CAS编号 | 124750-99-8 |
|---|---|
| 敏感性 | 对湿度敏感 |
| 熔点 | 183.5 - 184.5 °C |
| 溶解性 | Soluble in water (>500 mg/ml), PBS (pH 7.2) (≥10 mg/ml), ethanol (≥20 mg/ml), DMSO (100 mM), and DMF (≥20 mg/ml). |
| Reaxys-RN | 5900704 |
| RTECS | NI6755100 |
| MDL号 | MFCD02092704 |
| 分子量 | 461 |
| 分子式 | C22H22ClKN6O |
| 品牌 | 阿拉丁 |
| 备注 | 如果有可能，您尽量在同一天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。 |
| PubChem CID | 11751549 |