苏科商城

介绍

N-Phenylhydroxylamine is a useful synthetic intermediate. It was used as a reagent to prepare 6-halo-2-amino-3-formylchromones as potential topoisomerase inhibitor anticancer agents. It was also used in the synthesis of N-(chlorophenyl)cycloalkyl-hydroxamic acids and N-phenyl-N-hydroxycyclohexylacetamide with anti-viral activities.

用途

N-Phenylhydroxylamine can be used as a starting material for the synthesis of:

· 2-alkylindoles by treating with aliphatic terminal alkynes using gold catalyst via sequential 3,3-rearrangements and cyclodehydrations.

· Isoxazolidines by reacting with aldehydes and α, β-unsaturated aldehydes via a three-component one-pot catalytic reaction.

· Tetrahydro-1,2-oxazines by treating with an aldehyde and cyclopropane via homo 3+2 dipolar cycloaddition reaction

Introduction

N-Phenylhydroxylamine is a useful synthetic intermediate. It was used as a reagent to prepare 6-halo-2-amino-3-formylchromones as potential topoisomerase inhibitor anticancer agents. It was also used in the synthesis of N-(chlorophenyl)cycloalkyl-hydroxamic acids and N-phenyl-N-hydroxycyclohexylacetamide with anti-viral activities.

Application

N-Phenylhydroxylamine can be used as a starting material for the synthesis of:

· 2-alkylindoles by treating with aliphatic terminal alkynes using gold catalyst via sequential 3,3-rearrangements and cyclodehydrations.

· Isoxazolidines by reacting with aldehydes and α, β-unsaturated aldehydes via a three-component one-pot catalytic reaction.

· Tetrahydro-1,2-oxazines by treating with an aldehyde and cyclopropane via homo 3+2 dipolar cycloaddition reaction