￥
236.00起
Pinometostat (EPZ5676) ≥98%
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价格
￥236.00
货号
E125307-1mg
市场价
￥0.00
品牌
阿拉丁
销量
0
库存量
100
CAS号
1380288-87-8
分子式
C30H42N8O3
分子量
562.71
基本信息
| 产品名称 | Pinometostat (EPZ5676) |
|---|---|
| 英文名称 | Pinometostat (EPZ5676) |
| 别名 | EPZ-5676;EPZ5676;EPZ 5676 |
| 规格或纯度 | ≥98% |
| 生化机理 | The compound has a Ki value of 80 pM, and demonstrates 37,000-fold selectivity over all other methyltransferases tested. In cellular studies, EPZ-5676inhibited H3K79 methylation and MLL-fusion target gene expression and demonstrated potent cell killing that was selective for acute leukemia lines bearing MLL translocations. |
一般描述
EPZ-5676是氨基核苷类DOT1L组蛋白甲基转移酶抑制剂，Ki为80 pM，比对其它多种PMTs的抑制性高37000倍。
Pinometostat (EPZ5676) is an S-adenosyl methionine (SAM) competitive inhibitor of protein methyltransferase DOT1L with Ki of 80 pM in a cell-free assay, demonstrating >37,000-fold selectivity against all other PMTs tested, inhibits H3K79 methylation in tumor.
相关属性
| CAS编号 | 1380288-87-8 |
|---|---|
| 溶解性 | 25°C: DMSO |
| 储存温度 | 储存温度-20°C |
| 分子量 | 562.71 |
| 分子式 | C30H42N8O3 |
| 品牌 | 阿拉丁 |
| PubChem CID | 57345410 |