苏科商城

cAMP 和 cGMP 磷酸二脂酶的非专一性抑制剂。IBMX抑制了磷酸二脂酶，cAMP的增加激活了PKA ，其结果是减少增殖，增加分化和诱发凋亡. IBMX抑制由苯肾上腺素诱导的色胺（来自于神经内分泌上皮细胞的减少粘液IC50: 1.3 μM）的减少 。也作为腺苷受体拮抗剂。

Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons.