￥
39.00起
替莫唑胺 DNA烷基化/甲基化化疗剂 ≥98% (HPLC)
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价格
￥39.00
货号
T127425-250mg
市场价
￥0.00
品牌
阿拉丁
销量
0
库存量
100
CAS号
85622-93-1
分子式
C6H6N6O2
分子量
194.15
基本信息
| 产品名称 | 替莫唑胺 |
|---|---|
| 英文名称 | Temozolomide |
| 别名 | 替莫唑胺；3,4-二氢-3-甲基-4-氧代咪唑并[5,1-d]-1,2,3,5-四嗪-8-甲酰胺；8-氨甲酰-3-甲基咪唑[5,1-d]-1,2,3,5-四嗪-4(3H)-酮,；3-甲基-4-氧代-3,4-二氢咪唑并[5,1-d][1,2,3,5]四嗪-8-甲酰胺；4-甲基-5-氧代-2,3,4,6,8-五氮杂双环[4.3.0]壬基-2,7,9-三烯-9-甲酰胺 |
| 英文别名 | NSC 362856; CCRG 81045; TZM;3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide |
| 应用 | An apoptosis inducer which causes arrest at the G2/M cell cycle checkpoint. |
| 规格或纯度 | ≥98% (HPLC) |
| 运输条件 | 冰袋运输 |
| 生化机理 | Temozolomide is an antitumor, antiangiogenic compound that has been shown to work by alkylating DNA, typically throμgh addition of a methyl group to guanine in genomic DNA. The efficacy of this compound is dependent on its ability to methylate the DNA, thus triggering apoptosis; however, some cells are able to repair this damage via the enzymes O-6-methylguanine-DNA methyltransferase (MGMT). As a enzyme. Research has also been conducted to determine whether MGMT inhibitors such as O-6-benzylguanine might help to increase the efficacy of temozolomide. Furthermore, temozolomide has been implicated in causing arrest at the G2/M cell cycle checkpoint, which might also play a role in its cytotoxicity.DNA alkylating/methylating chemotherapeutic agent. Inhibits DNA replication. Anti-cancer and apoptotic activity in vitro and in vivo . Crosses the blood-brain barrier. |
一般描述
Temozolomide是一种DNA损伤诱导剂。An apoptosis inducer which causes arrest at the G2/M cell cycle checkpoint.
Temozolomide is a DNA damage inducer.
An apoptosis inducer which causes arrest at the G2/M cell cycle checkpoint.
安全信息
| 标识符号 | GHS08, GHS07 |
|---|---|
| 信号词 | Danger |
| 警示性声明 | P261,P305+P351+P338,P201,P308+P313 |
| 危害声明 | H315,H319,H335,H302,H360,H340,H350 |
| 个人防护设备 | Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
| WGK | 3 |
| Merck Index | 9139 |
相关属性
| CAS编号 | 85622-93-1 |
|---|---|
| 敏感性 | 对热敏感 |
| 熔点 | 206 °C(dec.) |
| 溶解性 | Soluble in water (5 mg/ml at 25 °C), DMSO (39 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C). |
| 储存温度 | 2-8°C储存,充氩 |
| Reaxys-RN | 5547136 |
| RTECS | NJ5927050 |
| MDL号 | MFCD00866492 |
| 分子量 | 194.15 |
| 分子式 | C6H6N6O2 |
| 品牌 | 阿拉丁 |
| 备注 | 如果有可能，您尽量在同一天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。 |
| PubChem CID | 5394 |