产品名称 | 4-氯-L-苯基丙氨酸 |
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英文名称 | 4-Chloro-L-phenylalanine |
别名 | L-4-氯苯丙氨酸;L-PCPA |
英文别名 | L-4-Chlorophenylalanine; H-Phe(4-Cl)-OH; (S)-2-Amino-3-(4-chlorophenyl)propionic acid; L-PCPA; p-Chloro-L-phenylalanine |
应用 | 色氨酸羟化酶(Tryptophan hydroxylase)抑制剂 |
规格或纯度 | 98% |
运输条件 | 超低温冰袋运输 |
生化机理 | 4-Chloro-L-phenylalanine (L-PCPA) inhibits the synthesis of 5-hydroxytryptamine (5-HT). 4-Chloro-DL-phenylalanine (PCPA) depletes the serotonin levels in the brain by its inhibitory effect on tryptophan hydroxylase (Tph). Studies support the protective effects of PCPA against monocrotaline-induced pulmonary vascular remodeling as well as in lung inflammation. |
色氨酸羟化酶(Tryptophan hydroxylase)抑制剂
Application
4-Chloro-L-phenylalanine (L-PCPA) has been used:
to block serotonin synthesis by inhibiting tryptophan hydroxylase (TPH)
to study its behavioral and electrographic effects on epileptic senegalese baboon (Papiopapio)
as a substrate for Chromobacteriumviolaceum phenylalanine hydroxylase
to incubate sea urchin embryos for immunohistochemistry
标识符号 | GHS06 |
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信号词 | Danger |
警示性声明 | P280,P301+P310 |
危害声明 | H301,H317 |
个人防护设备 | Eyeshields,Faceshields,Gloves,type P2 (EN 143) respirator cartridges |
WGK | 3 |
UN Number | 2811 |
CAS编号 | 14173-39-8 |
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熔点 | 235-238°C |
溶解性 | Soluble in acetic acid. Slightly soluble in water. |
储存温度 | -20°C储存 |
MDL号 | MFCD00063065 |
密度 | 1.336 |
分子量 | 199.63 |
分子式 | C9H10ClNO2 |
EC号 | 238-023-5 |
品牌 | 阿拉丁 |
PubChem CID | 736190 |