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基本信息
| 产品名称 | 卡莫司汀 |
|---|---|
| 英文名称 | Carmustine |
| 别名 | 卡莫司汀;卡氮芥；1,3-双(2-氯乙基)-1-亚硝基脲 |
| 英文别名 | 1,3-Bis(2-chloroethyl)-1-nitrosourea ;Nitrumon; Carmubris; Gliadel;BCNU |
| 应用 | A DNA alkylating and cross-linking agent used in the treatment of brain tumors and various other malignant neoplasmsv |
| 规格或纯度 | ≥98% |
| 运输条件 | 超低温冰袋运输 |
| 生化机理 | Carmustine is a member of the antineoplastic nitrosourea compounds. Carmustine can perform both alkylating and carabamoylating action and owes part of its cytotoxicity to its demonstrated ability to produce interstrand DNA cross linking. In addition, this compound has been documented as an inhibitor of glutathione reductase, trypanothione reductase, and lipoamide dehydrogenase (DLD).DNA alkylating agent. Forms interstrand crosslinks in DNA preventing DNA replication and transcription. Inhibitor of glutathione reductase, lipoamide dehydrogenase and trypanothione reductase. Active in vivo . |
一般描述
Carmustine is a cell-cycle phase nonspecific alkylating antineoplastic agentA DNA alkylating and cross-linking agent used in the treatment of brain tumors and various other malignant neoplasmsv
Carmustine is a cell-cycle phase nonspecific alkylating antineoplastic agent
A DNA alkylating and cross-linking agent used in the treatment of brain tumors and various other malignant neoplasms
General description：
Carmustine is a mustard gas related β-chloro-nitrosourea compound, which is used in chemotherapy. It inhibits DNA replication and DNA transcription.
Application：
Carmustine has been used to select transduced cells expressing MGMTP140K, a foamy virus vector. It has also been used in fluorescence-activated cell sorting (FACS) assay, to test the response of cell lines to carmustine.
安全信息
| 信号词 | Danger |
|---|---|
| 警示性声明 | P301+P310,P264,P201,P308+P313 |
| 危害声明 | H300,H360,H350 |
| 个人防护设备 | Eyeshields， Faceshields， full-face particle respirator type N100 (US)， Gloves， respirator cartridge type N100 (US)， type P1 (EN143) respirator filter， type P3 (EN 143) respirator cartridges |
| WGK | 3 |
| Merck Index | 1845 |
相关属性
| CAS编号 | 154-93-8 |
|---|---|
| 敏感性 | 对热敏感 |
| 熔点 | 32°C(lit.) |
| 溶解性 | Soluble in water (4 mg/ml), and 50% ethanol (150 mg/ml). |
| 储存温度 | -20°C储存,充氩 |
| Reaxys-RN | 2049744 |
| RTECS | YS2625000 |
| MDL号 | MFCD00057706 |
| 分子量 | 214.05 |
| 分子式 | C5H9Cl2N3O2 |
| 品牌 | 阿拉丁 |
| 备注 | 如果有可能，您尽量在同一天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。 |
| PubChem CID | 2578 |