| 产品名称 | 二硫化四乙基秋兰姆 |
|---|---|
| 英文名称 | Tetraethylthiuram disulfide |
| 别名 | 双硫伦;TETD;Disulfiram |
| 英文别名 | Disulfiram; Bis(diethylthiocarbamyl) disulfide; Bis(diethylthiocarbamoyl) disulfide; TETD |
| 应用 | 醇脱氢酶抑制剂。 An ALDH and tumor cell growth inhibitor |
| 规格或纯度 | 97% |
| 运输条件 | 常规运输 |
Disulfiram is a DNA demethylating agent and DIG1 inducer which inhibits prostate cancer cell growth by inhibition of DNA methyltransferase (Dnmt). In addition, studies indicate that disulfiram inhibits aldehyde dehydrogenase (ALDH) resulting in the accumulation of acetaldehyde upon ethanol ingestion. Alternate studies show that disulfiram also inhibits dopamine β-hydroxylase (DBH), an enzyme important in converting dopamine to norepinephrine in noradrenergic neurons. Futhermore, disulfiram can reduce toxicity and carcinogenesis by inhibiting the cytochrome P450IIE1 (CYP2E1). It has been reported that disulfiram can also inhibit tumor cell growth via binding to cellular copper, which inhibits proteosome activity and induces apoptosis. Disulfiram is an inhibitor of ADH and V-ATPase醇脱氢酶抑制剂。 An ALDH and tumor cell growth inhibitor
Disulfiram is a DNA demethylating agent and DIG1 inducer which inhibits prostate cancer cell growth by inhibition of DNA methyltransferase (Dnmt). In addition, studies indicate that disulfiram inhibits aldehyde dehydrogenase (ALDH) resulting in the accumulation of acetaldehyde upon ethanol ingestion. Alternate studies show that disulfiram also inhibits dopamine β-hydroxylase (DBH), an enzyme important in converting dopamine to norepinephrine in noradrenergic neurons. Futhermore, disulfiram can reduce toxicity and carcinogenesis by inhibiting the cytochrome P450IIE1 (CYP2E1). It has been reported that disulfiram can also inhibit tumor cell growth via binding to cellular copper, which inhibits proteosome activity and induces apoptosis. Disulfiram is an inhibitor of ADH and V-ATPase
An ALDH and tumor cell growth inhibitor
| 标识符号 | GHS08, GHS09, GHS07 |
|---|---|
| 警示性声明 | P273,P280,P501 |
| 危害声明 | H373,H302,H317,H410 |
| 个人防护设备 | dust mask type N95 (US),Eyeshields,Faceshields,Gloves |
| WGK | 3 |
| Merck Index | 3364 |
| UN Number | 3077 |
| CAS编号 | 97-77-8 |
|---|---|
| 熔点 | 69-71°C |
| 溶解性 | Soluble in water (4 mg/l at 25 °C), acohol (38.2 mg/ml), ether (71.4 mg/ml), chloroform, and acetonitrile |
| Reaxys-RN | 1712560 |
| RTECS | JO1225000 |
| MDL号 | MFCD00009048 |
| 密度 | 1.27 |
| 分子量 | 296.54 |
| 分子式 | C10H20N2S4 |
| EC号 | 202-607-8 |
| 品牌 | 阿拉丁 |
| 备注 | 250g卖完停产,不再备货 |
| PubChem CID | 3117 |