| 产品名称 | 三(2-羧乙基)膦盐酸盐 |
|---|---|
| 英文名称 | Tris(2-carboxyethyl)phosphine hydrochloride |
| 别名 | 三(2-羧乙基)磷盐酸盐;TCEP HCl;三(2-甲酰乙基)膦盐酸盐;三(2-羰基乙基)磷盐酸盐;TCEP |
| 英文别名 | tris(2-Carboxyethyl)phosphine;HCl;TCEP;Hydrochloride |
| 应用 | 水溶性试剂,用于二硫化物的选择性还原。在质谱应用中比 DTT 更稳定。 用于在水中进行的二硫化物选择性还原。 碱化后,该水溶性配体可通过水性洗涤反应粗产物实现钌系复分解催化剂的简单去除。 |
| 规格或纯度 | 98% |
| 运输条件 | 冰袋运输 |
| 生化机理 | 非硫醇还原剂。与DTT相比,在低pH下可更有效地还原脱氢抗坏血酸。在pH 1.5下还原至pH 9.0。反转NFκB-DNA结合的Mg 2+激发。 |
TCEP Hydrochloride is a water soluble, non-thiol, strong reducing agent shown to cleave disulfide bonds. Reports indicate that TCEP Hydrochloride can rapidly reduce stable alkyl disulfides, including DTT. TCEP Hydrochloride has been observed to reduce DHA in a solution of EDTA and metaphosphoric acid, and used to conduct proteolysis and Hydrogen/Deuterium exchange. Binding studies demonstrate that TCEP Hydrochloride does not bind Hg2+, and its binding efficacy to NF-κB-DNA has been tested in vitro.水溶性试剂,用于二硫化物的选择性还原。在质谱应用中比 DTT 更稳定。 用于在水中进行的二硫化物选择性还原。 碱化后,该水溶性配体可通过水性洗涤反应粗产物实现钌系复分解催化剂的简单去除。
TCEP Hydrochloride is a water soluble, non-thiol, strong reducing agent shown to cleave disulfide bonds. Reports indicate that TCEP Hydrochloride can rapidly reduce stable alkyl disulfides, including DTT. TCEP Hydrochloride has been observed to reduce DHA in a solution of EDTA and metaphosphoric acid, and used to conduct proteolysis and Hydrogen/Deuterium exchange. Binding studies demonstrate that TCEP Hydrochloride does not bind Hg2+, and its binding efficacy to NF-κB-DNA has been tested in vitro.
Reagent for the selective reduction of disulfides in water. Water soluble reagent, used for selective reduction of disulfides. More stable than DTT and useful in mass spectrometry applications. When basified, this water-soluble ligand allows for simple removal of ruthenium-derived metathesis catalysts via aqueous washing of a crude reaction mixture.
| 标识符号 | GHS05 |
|---|---|
| 信号词 | Danger |
| 警示性声明 | P305+P351+P338,P280,P310 |
| 危害声明 | H314 |
| 个人防护设备 | Faceshields,full-face respirator (US),Gloves,Goggles,multi-purpose combination respirator cartridge (US),type ABEK (EN14387) respirator filter |
| WGK | 2 |
| Merck Index | 9085 |
| UN Number | 3261 |
| CAS编号 | 51805-45-9 |
|---|---|
| 敏感性 | 对湿度、空气敏感 |
| 熔点 | 177°C |
| 溶解性 | Soluble in water (5 mg/ml), and methanol., Soluble in water (5 mg/ml), and methanol. |
| 储存温度 | 2-8°C储存,充氩 |
| Reaxys-RN | 3724376 |
| MDL号 | MFCD00145469 |
| 密度 | 1.041 |
| 分子量 | 286.65 |
| 分子式 | C9H15O6P·HCl |
| 品牌 | 阿拉丁 |
| 备注 | 如果有可能,您尽量在同一天配置溶液,并在当天使用完它。但是,如果您需要预先配制储备溶液,我们建议您将溶液等份保存在-20°C的密封小瓶中。通常,它们最多可以使用一个月。在使用前和打开样品瓶之前,我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度,用法和处理的建议吗?请访问我们的常见问题(FAQ)页面以获取更多详细信息。 |
| PubChem CID | 2734570 |